adipoyl hydrazide
Adipic dihydrazide
CAS: 1071-93-8
Molecular Formula: C6H14N4O2
adipoyl hydrazide - Names and Identifiers
| Name | Adipic dihydrazide |
| Synonyms | ADH Adipohydrazide ADIPODIHYDRAZIDE adipoyl hydrazide ADIPIC DIHYDRAZIDE Adipic dihydrazide ADIPINIC DIHYDRAZIDE ADIPIC ACID DIHYDRIZIDE ADIPIC ACID DIHYDRAZIDE |
| CAS | 1071-93-8 |
| EINECS | 213-999-5 |
| InChI | InChI=1/C6H14N4O2/c7-9-5(11)3-1-2-4-6(12)10-8/h1-4,7-8H2,(H,9,11)(H,10,12) |
adipoyl hydrazide - Physico-chemical Properties
| Molecular Formula | C6H14N4O2 |
| Molar Mass | 174.2 |
| Density | 1.186g/cm3 |
| Melting Point | 175-182℃ |
| Boling Point | 519.3°C at 760 mmHg |
| Flash Point | 267.9°C |
| Water Solubility | soluble |
| Vapor Presure | 6.92E-11mmHg at 25°C |
| Appearance | White crystal |
| Storage Condition | 2-8℃ |
| Sensitive | Sensitive to air |
| Refractive Index | 1.513 |
| MDL | MFCD00007614 |
| Physical and Chemical Properties | physical and chemical properties appearance white crystalline powder |
| Use | Mainly used for epoxy powder coating curing agent and coating additives, Metal deactivator and other polymer additives and water treatment agent |
adipoyl hydrazide - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. |
adipoyl hydrazide - Reference
| Reference Show more | 1. Zhang Xuan, Li Xiangwei, Song Wenlong, Ni Shilei, Qiu Ying, Liu Huimin, Li Na. Preparation and Cytotoxicity of Hyaluronic Acid Microspheres [J]. Journal of Practical Stomatology, 2020,36(06):954-958. 2. Zhao Yue. Design, Preparation and Biological Application of Bionic Intelligent Polymer Hydrogel Material [D]. Jilin University, 2020. 3. Li, Zhi-peng, et al. "Life-targeting and pH-sensitive sulfated hyaluronic acid mixed micelles for hepatoma therapy." International journal of nanomedicine 14 (2019): 9437.https://dx.doi.org/10.2147/IJN.S214528 4. [IF = 8.947] Zhao Yue et al. "The Infliximab-Based Self-Healing Hydrogel Composite Scaffold Enhances Stem Cells Survival, Engraftment, and Function in aiding Rheumatoid Arthritis Management." Acta Biomaterialia. 2020 Oct 05 5. [IF = 6.843] Chunhui Wu et al. "Light-responsive hyaluronic acid nanomicelles co-loaded with an IDO inhibitor focus targeted photoimmunotherapy against" immune cold "cancer." Biomater Sci-Uk. 2021 Oct;: 6. [IF = 5.115] Zhi-peng Li et al. "Love-Targeting and pH-Sensitive Sulfated hyaluronic Acid Mixed Micelles for Hepatoma Therapy." Int J Nanomed. 2019; 14: 9437-9452 |
adipoyl hydrazide - Introduction
Soluble in water, soluble in acetic acid, slightly soluble in acetone; insoluble in ethanol, ether and benzene
Last Update：2022-10-16 17:11:52
adipoyl hydrazide - Uses and synthesis methods
introduction
adipic acid dihydrazide (ADH) is the most suitable hydrazide crosslinking agent. ADH and diacetone acrylamide have been widely used in water-based paint emulsion. ADH is weakly alkaline, solid ADH is directly added to the emulsion may produce coalescence, usually ADH should be dissolved in hot water (poor solubility in cold water) and reused.
use
1. Adiacid dihydrazide bifunctional compound, which can be cross-linked with sodium hyaluronate as a protein drug carrier. It plays a cross-linking role with diacetone acrylamide in the post-crosslinking of water emulsion and water-soluble polymer, such as water-based coatings, adhesives, fibers, plastic film treatment, hair spray, etc., and can also be used as epoxy powder coating curing agent And water-based coating additives, metal deactivators and other polymer additives and water treatment agents, indoor formaldehyde adsorbents and intermediate raw materials.
2. the same bifunctional crosslinking reagent is specially used for aldehydes to generate relatively stable hydrazone links. In particular, it is used to connect glycoproteins, such as antibodies.
3. The same type of bifunctional linker for aldehydes can produce relatively stable hydrazone linkage; for the linkage of carbohydrate proteins, such as antibodies, periodate oxidation reaction occurs at a specific form of position; at pH 5.0, oxidation reaction and coupling reaction can be carried out conveniently, hydrazide derived from low pKa value can avoid competitive reaction through primary amine
4, mainly used for epoxy powder coating curing agent and coating additives, metal deactivator and other polymer additives and water treatment agents
category
toxic substances
toxicity classification
Poisoning
acute toxicity
non-intestinal-rat LDL0: 4000 mg/kg
flammability hazard characteristics
Flammable; combustion releases toxic nitrogen oxide smoke
storage and transportation features
The warehouse is ventilated and dry at low temperature; stored separately from food ingredients
fire extinguishing agent
Dry powder, foam, sand, carbon dioxide, mist water
Last Update：2024-04-10 22:29:15
adipoyl hydrazide - Nature
| storage conditions | -20°C |
| solubility | H2O: 100 mg/mL |
| acidity coefficient (pKa) | 12.93±0.35(Predicted) |
| morphology | Crystalline Powder |
| color | White to slightly yellow |
| water solubility | soluble |
| BRN | 973863 |
| InChIKey | IBVAQQYNSHJXBV-UHFFFAOYSA-N |
| NIST chemical information | Adipic dihydrazide(1071-93-8) |
| EPA chemical information | Hexanedioic acid, dihydrazide (1071-93-8) |
Last Update：2024-04-10 22:29:15
adipoyl hydrazide - Security information
| WGK Germany | 3 |
| RTECS number | AV1400000 |
| auto-ignition temperature | 360 °C |
| Hazard Note | Irritant |
| TSCA | Yes |
| HazardClass | IRRITANT |
| customs code | 29280090 |
Last Update：2024-04-10 22:29:15
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